Drug: Deconsal DM

Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets are an antihistamine/nasal decongestant/antitussive combination for oral administration as a chewable tablet. Each Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablet in a grape-flavored, dye-free, mottled brown-colored, scored tablet for oral administration contains: Phenylephrine HCl.................10 mg
Pyrilamine Maleate................16 mg
Dextromethorphan HBr...........15 mg Inactive ingredients: Citric acid, calcium phosphate dibasic, hypromellose, grape flavor, magnesium aluminum silicate, magnesium stearate, compressible sugar, corn starch, mannitol, sucralose, talc, tannic acid, and xanthan gum. See DOSAGE AND ADMINISTRATION section for further descriptive composition.Last reviewed on RxList: 5/4/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

The most common effects associated with antihistamines have been drowsiness sedation, dryness of mucous membranes, and gastrointestinal effects. Serious side effects with oral antihistamines, sympathomimetics, and antitussives have been rare. Other adverse reactions may include: Dermatologic - urticaria, drug rash, photosensitivity, pruritus. Cardiovascular - hypotension, hypertension, cardiac arrhythmias, palpitations. Central Nervous Systems (CNS) - disturbed coordination, tremor, irritability, insomnia, visual disturbances, weakness, nervousness, convulsion, headache, euphoria, and dysphoria. Genitourinary - urinary frequency, difficult urination. Gastrointestinal - epigastric discomfort, anorexia, nausea, vomiting, diarrhea, constipation. Respiratory - tightness of the chest and wheezing, shortness of breath. Hematologic - hemolytic anemia, thrombocytopenia, agranulocytosis. Read the Deconsal DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Side Effects Center for a complete guide to possible side effectsLearn More »

Source: http://www.rxlist.com

Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets: Administer the recommended dose every 12 hours. 12 years and older - 1 to 2 tablets; 6 to 12 years of age - !4 to 1 tablet.

Source: http://www.rxlist.com

MAO inhibitors may prolong and intensify the anticholinergic effects of sympathomimetic agents. Patients may develop hyperpyrexia, hypotension, nausea, myoclonic leg jerks, and coma following coadministration of MAO inhibitors and dextromethorphan. Thus, concomitant administration of Deconsal® DM Tannate Chewable Tablets and MAO inhibitors should be avoided (see "CONTRAINDICATIONS"). Last reviewed on RxList: 5/4/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets are indicated for the symptomatic relief of coryza, nasal congestion, and cough associated with the common cold, sinusitis, allergic rhinitis, and other upper respiratory tract conditions. Appropriate therapy should be provided for the primary disease.

Source: http://www.rxlist.com

Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets are contraindicated in patients sensitive to any of the ingredients or related compounds. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma. Phenylephrine is contraindicated in patients with hypertension or with peripheral vascular insufficiency (ischemia may result with risk of gangrene or thrombosis of compromised vascular beds). Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets should not be used in patients receiving a monoamine oxidase inhibitor (MAOI) (see "PRECAUTIONS-DRUG INTERACTIONS"). Last reviewed on RxList: 5/4/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

Signs And Symptoms May vary from CNS depression to stimulation (restlessness to convulsions). Antihistamine overdosage in young children may lead to convulsions and death. Atropine-like signs and symptoms may be prominent. Dextromethorphan may produce central excitement and mental confusion. Very high doses of dextromethorphan may produce respiratory depression. Treatment Induce vomiting if it has not occurred spontaneously. Precautions must be taken against aspiration especially in infants, children, and comatose patients. If gastric lavage is indicated, isotonic or half-isotonic saline solution is preferred. Stimulants should not be used. If hypotension is a problem, vasopressor agents may be considered.

Source: http://www.rxlist.com

Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets are available as grape-flavored, dye-free, mottled brown-colored, scored tablet imprinted with CT on one side and the score line on the other NDC No.: 10122-203-10 - Bottles of 100 Chewable Tablets and NDC No.: 10122-203-02 single tablet sample pouches. Store at controlled room temperature, 20°-25° C (68° -77° F). Dispense in a tight, light-resistant container (USP/NF) with a child-resistant closure. Protect from moisture. Manufactured for: Cornerstone BioPharma, Inc. Cary, NC 27518. Last reviewed on RxList: 5/4/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

General Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients and therefore should be used with caution. Antihistamines may cause excitation, particularly in pediatric patients, but their combination with sympathomimetics may cause either mild stimulation or mild sedation. Use with caution in patients with hypertension, cardiovascular disease, hyperthyroidism, diabetes, or narrow angle glaucoma. Dextromethorphan should be used with caution in sedated patients, and in patients confined to the supine position. Carcinogenesis, Mutagenesis, Impairment Of Fertility No long-term animal studies have been performed with Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets. Pregnancy Teratogenic Effects- Pregnancy Category C Animal reproduction studies have not been conducted with Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets. It is also not known whether Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Chewable Tablets should be given to a pregnant woman only if clearly needed. Labor and Delivery Administration of phenylephrine to patients in late pregnancy or labor may cause fetal anoxia or bradycardia by increasing contractility of the uterus and decreasing uterine blood flow. Nursing Mothers Because of the higher risk of intolerance of antihistamines in small infants generally, and in newborns and prematures in particular, Deconsal® DM (phenylephrine, pyrilamine maleate, and dextromethorphan hbr) Tannate Tablets should not be administered to a nursing mother. Last reviewed on RxList: 5/4/2009
This monograph has been modified to include the generic and brand name in many instances.

Source: http://www.rxlist.com

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